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Mechanical Signal Influence on Mesenchymal Stem Cell Fate is Enhanced by Incorporation of Refractory Periods into the Loading Regimen

Mechanical signals of both low and high intensity are inhibitory to fat and anabolic to bone in vivo, and have been shown to directly affect mesenchymal stem cell pools from which fat and bone precursors emerge. To identify an idealized mechanical regimen which can regulate MSC fate, low intensity v...

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Main Authors: Sen, Buer, Xie, Zhihui, Case, Natasha, Styner, Maya, Rubin, Clinton T, Rubin, Janet
Format: Artigo
Jezik:Inglês
Izdano: 2010
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3042527/
https://ncbi.nlm.nih.gov/pubmed/21130997
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jbiomech.2010.11.022
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