Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

The fate of pluripotent mesenchymal stem cells (MSC) is determined through integration of chemical, spatial, and physical signals. The suppression of MSC adipogenesis by mechanical stimuli, which requires Akt-induced inhibition of glycogen synthase kinase 3β (GSK3β) with β-catenin activation, can be...

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Autors principals: Sen, Buer, Guilluy, Christophe, Xie, Zhihui, Case, Natasha, Styner, Maya, Thomas, Jacob, Oguz, Ipek, Rubin, Clinton, Burridge, Keith, Rubin, Janet
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588570/
https://ncbi.nlm.nih.gov/pubmed/21898699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.732
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