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Mechanically Induced Focal Adhesion Assembly Amplifies Anti-Adipogenic Pathways in Mesenchymal Stem Cells

The fate of pluripotent mesenchymal stem cells (MSC) is determined through integration of chemical, spatial, and physical signals. The suppression of MSC adipogenesis by mechanical stimuli, which requires Akt-induced inhibition of glycogen synthase kinase 3β (GSK3β) with β-catenin activation, can be...

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Detalhes bibliográficos
Main Authors: Sen, Buer, Guilluy, Christophe, Xie, Zhihui, Case, Natasha, Styner, Maya, Thomas, Jacob, Oguz, Ipek, Rubin, Clinton, Burridge, Keith, Rubin, Janet
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3588570/
https://ncbi.nlm.nih.gov/pubmed/21898699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.732
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