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Mechanical input restrains PPARγ2 expression and action to preserve mesenchymal stem cell multipotentiality
Exercise-generated signals are pro-osteogenic and anti-adipogenic within the marrow. In vitro studies indicate that mechanical signals directly block adipogenic differentiation through activation of β-catenin and by limiting PPARγ2 expression. Whether mechanically generated β-catenin can inhibit adi...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3535265/ https://ncbi.nlm.nih.gov/pubmed/22951341 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bone.2012.08.122 |
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