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Degradation of cyclin A is regulated by acetylation

Cyclin A accumulates at the onset of S phase, rem ains high during G(2) and early mitosis and is degraded at prometaphase. Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54,68, 95 and 112. Maximal acetylation occu...

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Autors principals: Mateo, F, Vidal-Laliena, M, Canela, N, Busino, L, Martinez-Balbas, MA, Pagano, M, Agell, N, Bachs, O
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869789/
https://ncbi.nlm.nih.gov/pubmed/19483727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.127
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