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Degradation of cyclin A is regulated by acetylation
Cyclin A accumulates at the onset of S phase, rem ains high during G(2) and early mitosis and is degraded at prometaphase. Here, we report that the acetyltransferase P/CAF directly interacts with cyclin A that as a consequence becomes acetylated at lysines 54,68, 95 and 112. Maximal acetylation occu...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3869789/ https://ncbi.nlm.nih.gov/pubmed/19483727 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.127 |
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