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Regulation of E2F1 activity by acetylation
During the G(1) phase of the cell cycle, an E2F–RB complex represses transcription, via the recruitment of histone deacetylase activity. Phosphorylation of RB at the G(1)/S boundary generates a pool of ‘free’ E2F, which then stimulates transcription of S-phase genes. Given that E2F1 activity is stim...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2000
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC305604/ https://ncbi.nlm.nih.gov/pubmed/10675335 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.4.662 |
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