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Regulation of E2F1 activity by acetylation

During the G(1) phase of the cell cycle, an E2F–RB complex represses transcription, via the recruitment of histone deacetylase activity. Phosphorylation of RB at the G(1)/S boundary generates a pool of ‘free’ E2F, which then stimulates transcription of S-phase genes. Given that E2F1 activity is stim...

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Bibliografiske detaljer
Main Authors: Martínez-Balbás, Marian A., Bauer, Uta-Maria, Nielsen, Søren J., Brehm, Alexander, Kouzarides, Tony
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2000
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC305604/
https://ncbi.nlm.nih.gov/pubmed/10675335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/emboj/19.4.662
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