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Nickel/Bis(oxazoline)-Catalyzed Asymmetric Negishi Arylations of Racemic Secondary Benzylic Electrophiles to Generate Enantioenriched 1,1-Diaryalkanes

A tertiary stereogenic center that bears two different aryl substituents is found in a variety of bioactive compounds, including medicines such as Zoloft(™) and Detrol(™). We have developed an efficient method for the synthesis of enantioenriched 1,1-diarylalkanes from readily available racemic benz...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Do, Hien-Quang, Chandrashekar, E. R. R., Fu, Gregory C.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3869004/
https://ncbi.nlm.nih.gov/pubmed/24164502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja408561b
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