A Complex Relationship between TRAF3 and Non-Canonical NF-κB2 Activation in B Lymphocytes

The adaptor protein TRAF3 restrains B cell activating factor receptor (BAFFR) and CD40-mediated activation of the NF-κB2 pathway in B cells. Mice lacking TRAF3 specifically in B cells revealed the critical role of TRAF3 in restraining homeostatic B cell survival. Furthermore, loss-of-function mutati...

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Bibliographic Details
Main Authors: Lin, Wai W., Hildebrand, Joanne M., Bishop, Gail A.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2013
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868921/
https://ncbi.nlm.nih.gov/pubmed/24391649
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2013.00477
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