Perturbation Biology: Inferring Signaling Networks in Cellular Systems

We present a powerful experimental-computational technology for inferring network models that predict the response of cells to perturbations, and that may be useful in the design of combinatorial therapy against cancer. The experiments are systematic series of perturbations of cancer cell lines by t...

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Bibliografiske detaljer
Main Authors: Molinelli, Evan J., Korkut, Anil, Wang, Weiqing, Miller, Martin L., Gauthier, Nicholas P., Jing, Xiaohong, Kaushik, Poorvi, He, Qin, Mills, Gordon, Solit, David B., Pratilas, Christine A., Weigt, Martin, Braunstein, Alfredo, Pagnani, Andrea, Zecchina, Riccardo, Sander, Chris
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868523/
https://ncbi.nlm.nih.gov/pubmed/24367245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1003290
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