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Perturbation biology links temporal protein changes to drug responses in a melanoma cell line

Cancer cells have genetic alterations that often directly affect intracellular protein signaling processes allowing them to bypass control mechanisms for cell death, growth and division. Cancer drugs targeting these alterations often work initially, but resistance is common. Combinations of targeted...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Nyman, Elin, Stein, Richard R., Jing, Xiaohong, Wang, Weiqing, Marks, Benjamin, Zervantonakis, Ioannis K., Korkut, Anil, Gauthier, Nicholas P., Sander, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7384681/
https://ncbi.nlm.nih.gov/pubmed/32667922
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007909
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