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Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells
Resistance to targeted cancer therapies is an important clinical problem. The discovery of anti-resistance drug combinations is challenging as resistance can arise by diverse escape mechanisms. To address this challenge, we improved and applied the experimental-computational perturbation biology met...
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| Udgivet i: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
eLife Sciences Publications, Ltd
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4539601/ https://ncbi.nlm.nih.gov/pubmed/26284497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04640 |
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