Perturbation biology nominates upstream–downstream drug combinations in RAF inhibitor resistant melanoma cells

Resistance to targeted cancer therapies is an important clinical problem. The discovery of anti-resistance drug combinations is challenging as resistance can arise by diverse escape mechanisms. To address this challenge, we improved and applied the experimental-computational perturbation biology met...

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Bibliographic Details
Published in:eLife
Main Authors: Korkut, Anil, Wang, Weiqing, Demir, Emek, Aksoy, Bülent Arman, Jing, Xiaohong, Molinelli, Evan J, Babur, Özgün, Bemis, Debra L, Onur Sumer, Selcuk, Solit, David B, Pratilas, Christine A, Sander, Chris
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4539601/
https://ncbi.nlm.nih.gov/pubmed/26284497
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.04640
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