Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway

Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function is impaired in diabetic individuals. Furthermore, the expression of Opa-1 and mi...

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主要な著者: Parra, Valentina, Verdejo, Hugo E., Iglewski, Myriam, del Campo, Andrea, Troncoso, Rodrigo, Jones, Deborah, Zhu, Yi, Kuzmicic, Jovan, Pennanen, Christian, Lopez‑Crisosto, Camila, Jaña, Fabián, Ferreira, Jorge, Noguera, Eduard, Chiong, Mario, Bernlohr, David A., Klip, Amira, Hill, Joseph A., Rothermel, Beverly A., Abel, Evan Dale, Zorzano, Antonio, Lavandero, Sergio
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2014
主題:
Metabolism
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868041/
https://ncbi.nlm.nih.gov/pubmed/24009260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0340
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