Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway

Insulin regulates heart metabolism through the regulation of insulin-stimulated glucose uptake. Studies have indicated that insulin can also regulate mitochondrial function. Relevant to this idea, mitochondrial function is impaired in diabetic individuals. Furthermore, the expression of Opa-1 and mi...

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Autors principals: Parra, Valentina, Verdejo, Hugo E., Iglewski, Myriam, del Campo, Andrea, Troncoso, Rodrigo, Jones, Deborah, Zhu, Yi, Kuzmicic, Jovan, Pennanen, Christian, Lopez‑Crisosto, Camila, Jaña, Fabián, Ferreira, Jorge, Noguera, Eduard, Chiong, Mario, Bernlohr, David A., Klip, Amira, Hill, Joseph A., Rothermel, Beverly A., Abel, Evan Dale, Zorzano, Antonio, Lavandero, Sergio
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2014
Matèries:
Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3868041/
https://ncbi.nlm.nih.gov/pubmed/24009260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db13-0340
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