Alteration in mitochondrial Ca(2+) uptake disrupts insulin signaling in hypertrophic cardiomyocytes

BACKGROUND: Cardiac hypertrophy is characterized by alterations in both cardiac bioenergetics and insulin sensitivity. Insulin promotes glucose uptake by cardiomyocytes and its use as a substrate for glycolysis and mitochondrial oxidation in order to maintain the high cardiac energy demands. Insulin...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Gutiérrez, Tomás, Parra, Valentina, Troncoso, Rodrigo, Pennanen, Christian, Contreras-Ferrat, Ariel, Vasquez-Trincado, César, Morales, Pablo E, Lopez-Crisosto, Camila, Sotomayor-Flores, Cristian, Chiong, Mario, Rothermel, Beverly A, Lavandero, Sergio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234850/
https://ncbi.nlm.nih.gov/pubmed/25376904
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-014-0068-4
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