KIT oncogene inhibition drives intratumoral macrophage M2 polarization

Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulation of TAMs is under intense investigation because they are thought to be nearly always of the M2 subtype, which supports tumor growth. Gastrointestinal stromal tumor (GIST) is the most common human sarc...

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Main Authors: Cavnar, Michael J., Zeng, Shan, Kim, Teresa S., Sorenson, Eric C., Ocuin, Lee M., Balachandran, Vinod P., Seifert, Adrian M., Greer, Jonathan B., Popow, Rachel, Crawley, Megan H., Cohen, Noah A., Green, Benjamin L., Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R., DeMatteo, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865475/
https://ncbi.nlm.nih.gov/pubmed/24323358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130875
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