KIT oncogene inhibition drives intratumoral macrophage M2 polarization

Tumor-associated macrophages (TAMs) are a major component of the cancer microenvironment. Modulation of TAMs is under intense investigation because they are thought to be nearly always of the M2 subtype, which supports tumor growth. Gastrointestinal stromal tumor (GIST) is the most common human sarc...

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Detalhes bibliográficos
Main Authors: Cavnar, Michael J., Zeng, Shan, Kim, Teresa S., Sorenson, Eric C., Ocuin, Lee M., Balachandran, Vinod P., Seifert, Adrian M., Greer, Jonathan B., Popow, Rachel, Crawley, Megan H., Cohen, Noah A., Green, Benjamin L., Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R., DeMatteo, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3865475/
https://ncbi.nlm.nih.gov/pubmed/24323358
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20130875
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