Pharmacological inhibition of KIT activates MET signaling in gastrointestinal stromal tumors

Gastrointestinal stromal tumors (GIST) are the most common adult sarcomas and the oncogenic driver is usually a KIT or PDGFRA mutation. While GIST are often initially sensitive to imatinib or other tyrosine kinase inhibitors, resistance generally develops necessitating backup strategies for therapy....

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Cohen, Noah A., Zeng, Shan, Seifert, Adrian M., Kim, Teresa S., Sorenson, Eric C., Greer, Jonathan B., Beckman, Michael J., Santamaria-Barria, Juan A., Crawley, Megan H., Green, Benjamin L., Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R., DeMatteo, Ronald P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4467991/
https://ncbi.nlm.nih.gov/pubmed/25836719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-2564
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados