PD-1/PD-L1 blockade enhances T cell activity and antitumor efficacy of imatinib in gastrointestinal stromal tumors

PURPOSE: Tyrosine kinase inhibitors are effective in gastrointestinal stromal tumor (GIST), but often are of transient benefit as resistance commonly develops. Immunotherapy, particularly blockade of the inhibitory receptor programmed death 1 (PD-1) or the ligand programmed death ligand 1 (PD-L1), h...

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Publicado en:Clin Cancer Res
Autores principales: Seifert, Adrian M., Zeng, Shan, Zhang, Jennifer Q., Kim, Teresa S., Cohen, Noah A., Beckman, Michael J., Medina, Benjamin D., Maltbaek, Joanna H., Loo, Jennifer K., Crawley, Megan H., Rossi, Ferdinand, Besmer, Peter, Antonescu, Cristina R., DeMatteo, Ronald P.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5241182/
https://ncbi.nlm.nih.gov/pubmed/27470968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1163
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