Phospholamban Knockout Breaks Arrhythmogenic Ca(2+) Waves and Suppresses Catecholaminergic Polymorphic Ventricular Tachycardia in Mice

RATIONALE: Phospholamban (PLN) is an inhibitor of cardiac sarco(endo)plasmic reticulum Ca(2+) ATPase (SERCA2a). PLN knockout (PLN-KO) enhances sarcoplasmic reticulum (SR) Ca(2+) load and Ca(2+) leak. Conversely, PLN-KO accelerates Ca(2+) sequestration and aborts arrhythmogenic spontaneous Ca(2+) wav...

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Autors principals: Bai, Yunlong, Jones, Peter P., Guo, Jiqing, Zhong, Xiaowei, Clark, Robert B., Zhou, Qiang, Wang, Ruiwu, Vallmitjana, Alexander, Benitez, Raul, Hove-Madsen, Leif, Semeniuk, Lisa, Guo, Ang, Song, Long-Sheng, Duff, Henry J., Chen, S.R. Wayne
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864692/
https://ncbi.nlm.nih.gov/pubmed/23856523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.113.301678
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