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Inducing host protection in pneumococcal sepsis by preactivation of the Ashwell-Morell receptor

The endocytic Ashwell-Morell receptor (AMR) of hepatocytes detects pathogen remodeling of host glycoproteins by neuraminidase in the bloodstream and mitigates the lethal coagulopathy of sepsis. We have investigated the mechanism of host protection by the AMR during the onset of sepsis and in respons...

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Main Authors: Grewal, Prabhjit K., Aziz, Peter V., Uchiyama, Satoshi, Rubio, Gabriel R., Lardone, Ricardo D., Le, Dzung, Varki, Nissi M., Nizet, Victor, Marth, Jamey D.
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2013
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864324/
https://ncbi.nlm.nih.gov/pubmed/24284176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1313905110
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