The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling

The hepatic Ashwell-Morell receptor (AMR) can bind and remove desialylated platelets. We demonstrate that platelets become desialylated as they circulate and age in blood. Binding of desialylated platelets to the AMR induces hepatic thrombopoietin (TPO) gene transcription and translation, thereby re...

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Bibliografiske detaljer
Udgivet i:Nat Med
Main Authors: Grozovsky, Renata, Begonja, Antonija Jurak, Liu, Kaifeng, Visner, Gary, Hartwig, John H., Falet, Hervé, Hoffmeister, Karin M.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4303234/
https://ncbi.nlm.nih.gov/pubmed/25485912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3770
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