FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly

Filamin A (FlnA) is a large cytoplasmic protein that crosslinks actin filaments and anchors membrane receptors and signaling intermediates. FlnA(loxP) PF4-Cre mice that lack FlnA in the megakaryocyte (MK) lineage have a severe macrothrombocytopenia because of accelerated platelet clearance. Macropha...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Jurak Begonja, Antonija, Hoffmeister, Karin M., Hartwig, John H., Falet, Hervé
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2011
Gaiak:
Platelets and Thrombopoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3162356/
https://ncbi.nlm.nih.gov/pubmed/21652675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-348482
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