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FlnA-null megakaryocytes prematurely release large and fragile platelets that circulate poorly
Filamin A (FlnA) is a large cytoplasmic protein that crosslinks actin filaments and anchors membrane receptors and signaling intermediates. FlnA(loxP) PF4-Cre mice that lack FlnA in the megakaryocyte (MK) lineage have a severe macrothrombocytopenia because of accelerated platelet clearance. Macropha...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society of Hematology
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3162356/ https://ncbi.nlm.nih.gov/pubmed/21652675 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-04-348482 |
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