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A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function
Filamin A (FlnA) cross-links actin filaments and connects the Von Willebrand factor receptor GPIb-IX-V to the underlying cytoskeleton in platelets. Because FlnA deficiency is embryonic lethal, mice lacking FlnA in platelets were generated by breeding FlnA(loxP/loxP) females with GATA1-Cre males. Fln...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2931168/ https://ncbi.nlm.nih.gov/pubmed/20713593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20100222 |
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