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The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling
The hepatic Ashwell-Morell receptor (AMR) can bind and remove desialylated platelets. We demonstrate that platelets become desialylated as they circulate and age in blood. Binding of desialylated platelets to the AMR induces hepatic thrombopoietin (TPO) gene transcription and translation, thereby re...
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| 發表在: | Nat Med |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4303234/ https://ncbi.nlm.nih.gov/pubmed/25485912 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.3770 |
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