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Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins

The molecular basis for the diversity across influenza strains is poorly understood. To gain insight into this question, we mutagenized the viral genome and sequenced recoverable viruses. Only two small regions in the genome were enriched for insertions, the hemagglutinin head and the immune-modulat...

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Autors principals: Heaton, Nicholas S., Sachs, David, Chen, Chi-Jene, Hai, Rong, Palese, Peter
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3864309/
https://ncbi.nlm.nih.gov/pubmed/24277853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320524110
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