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Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins
The molecular basis for the diversity across influenza strains is poorly understood. To gain insight into this question, we mutagenized the viral genome and sequenced recoverable viruses. Only two small regions in the genome were enriched for insertions, the hemagglutinin head and the immune-modulat...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3864309/ https://ncbi.nlm.nih.gov/pubmed/24277853 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1320524110 |
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