Discovery of Plasmodium vivax N–Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

N-myristoyltransferase (NMT) is a prospective drug target against parasitic protozoa. Herein we report the successful discovery of a series of Plasmodium vivax NMT inhibitors by high throughput screening. A high-resolution crystal structure of the hit compound in complex with NMT was obtained, allow...

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Bibliographische Detailangaben
Hauptverfasser: Goncalves, Victor, Brannigan, James A., Whalley, David, Ansell, Keith H., Saxty, Barbara, Holder, Anthony A., Wilkinson, Anthony J., Tate, Edward W., Leatherbarrow, Robin J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863987/
https://ncbi.nlm.nih.gov/pubmed/22439843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm300040p
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