Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

Peripherally acting opioids are potentially attractive drugs for the clinical management of certain chronic pain states due to the lack of centrally mediated adverse effects. However, it remains unclear whether tolerance develops to peripheral opioid analgesic effects under neuropathic pain conditio...

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Detalhes bibliográficos
Main Authors: He, Shao-Qiu, Yang, Fei, Perez, Federico M., Xu, Qian, Shechter, Ronen, Cheong, Yong-Kwan, Carteret, Alene F., Dong, Xinzhong, Sweitzer, Sarah M., Raja, Srinivasa N., Guan, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863910/
https://ncbi.nlm.nih.gov/pubmed/23880055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.07.023
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