Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

Peripherally acting opioids are potentially attractive drugs for the clinical management of certain chronic pain states due to the lack of centrally mediated adverse effects. However, it remains unclear whether tolerance develops to peripheral opioid analgesic effects under neuropathic pain conditio...

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Hlavní autoři: He, Shao-Qiu, Yang, Fei, Perez, Federico M., Xu, Qian, Shechter, Ronen, Cheong, Yong-Kwan, Carteret, Alene F., Dong, Xinzhong, Sweitzer, Sarah M., Raja, Srinivasa N., Guan, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863910/
https://ncbi.nlm.nih.gov/pubmed/23880055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pain.2013.07.023
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