Analgesic properties of loperamide differ following systemic and local administration to rats after spinal nerve injury

BACKGROUND: The analgesic properties and mechanisms of loperamide hydrochloride, a peripherally acting opioid receptor agonist, in neuropathic pain warrant further investigation. METHODS: We examined the effects of systemic or local administration of loperamide on heat and mechanical hyperalgesia in...

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Autors principals: Chung, Chih-yang, Carteret, Alene F., McKelvy, Alvin D., Ringkamp, Matthias, Yang, Fei, Hartke, Timothy V., Dong, Xinzhong, Raja, Srinivasa N., Guan, Yun
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3389202/
https://ncbi.nlm.nih.gov/pubmed/22508374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/j.1532-2149.2012.00148.x
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