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Local Loperamide Injection Reduces Mechanosensitivity of Rat Cutaneous, Nociceptive C-Fibers

Loperamide reverses signs of mechanical hypersensitivity in an animal model of neuropathic pain suggesting that peripheral opioid receptors may be suitable targets for the treatment of neuropathic pain. Since little is known about loperamide effects on the responsiveness of primary afferent nerve fi...

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Détails bibliographiques
Auteurs principaux: Ringkamp, Matthias, Tal, Michael, Hartke, Timothy V., Wooten, Matthew, McKelvy, Alvin, Turnquist, Brian P., Guan, Yun, Meyer, Richard A., Raja, Srinivasa N.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2012
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3405035/
https://ncbi.nlm.nih.gov/pubmed/22848720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0042105
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