Activation of Peripheral Mu-Opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) amide Leads to Modality-preferred Inhibition of Neuropathic Pain

BACKGROUND: Opioids have long been regarded as the most effective drugs for treatment of severe acute and chronic pain. Unfortunately, their therapeutic efficacy and clinical utility has been limited because of central and peripheral side effects. METHODS: To determine the therapeutic value of perip...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Tiwari, Vinod, Yang, Fei, He, Shao-Qiu, Shechter, Ronen, Zhang, Chen, Shu, Bin, Zhang, Tong, Tiwari, Vineeta, Wang, Yun, Dong, Xinzhong, Guan, Yun, Raja, Srinivasa N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4755859/
https://ncbi.nlm.nih.gov/pubmed/26756519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000000993
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