Peripherally acting mu-opioid receptor agonists attenuate ongoing pain-associated behavior and spontaneous neuronal activity after nerve injury in rats

BACKGROUND: Ongoing neuropathic pain is difficult to treat. We examined whether dermorphin [D-Arg2, Lys4] (1–4) amide (DALDA), a peripherally acting mu-opioid receptor agonist, attenuates ongoing pain-associated manifestations after nerve injury in rats and mice. METHODS: Using conditioned place pre...

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Detalhes bibliográficos
Publicado no:Anesthesiology
Main Authors: Tiwari, Vinod, Anderson, Michael, Yang, Fei, Tiwari, Vineeta, Pharm, M., Zheng, Qin, He, Shao-Qiu, Zhang, Tong, Shu, Bin, Chen, Xueming, Grenald, Shaness A., Stephens, Kimberly E., Chen, Zhiyong, Dong, Xinzhong, Raja, Srinivasa N., Guan, Yun
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5953805/
https://ncbi.nlm.nih.gov/pubmed/29601322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/ALN.0000000000002191
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