R-flurbiprofen improves tau, but not Aß pathology in a triple transgenic model of Alzheimer's disease

We have previously reported that chronic ibuprofen treatment improves cognition and decreases intracellular Aß and phosphorylated-tau levels in 3xTg-AD mice. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that independently of its anti-inflammatory effects has anti-amyloidogenic activit...

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Main Authors: Carreras, Isabel, McKee, Ann C., Choi, Ji-Kyung, Aytan, Nurgul, Kowall, Neil W., Jenkins, Bruce G., Dedeoglu, Alpaslan
Formato: Artigo
Idioma:Inglês
Publicado: 2013
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3863610/
https://ncbi.nlm.nih.gov/pubmed/24161403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2013.10.025
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