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Dual dose-dependent effects of fingolimod in a mouse model of Alzheimer’s disease
Lipid metabolism is abnormal in Alzheimer’s disease (AD) brain leading to ceramide and sphingosine accumulation and reduced levels of brain sphingosine-1-phosphate (S1P). We hypothesize that changes in S1P signaling are central to the inflammatory and immune-pathogenesis of AD and the therapeutic be...
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| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6662857/ https://ncbi.nlm.nih.gov/pubmed/31358793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47287-1 |
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