Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). We conducted a clinical trial of allogeneic T cells genetically modified to express a chimeric antigen receptor (CAR) targeting the B-cell antigen CD19. T cells for genet...

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Hauptverfasser: Kochenderfer, James N., Dudley, Mark E., Carpenter, Robert O., Kassim, Sadik H., Rose, Jeremy J., Telford, William G., Hakim, Frances T., Halverson, David C., Fowler, Daniel H., Hardy, Nancy M., Mato, Anthony R., Hickstein, Dennis D., Gea-Banacloche, Juan C., Pavletic, Steven Z., Sportes, Claude, Maric, Irina, Feldman, Steven A., Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Jena, Bipulendu, Bishop, Michael R., Gress, Ronald E., Rosenberg, Steven A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2013
Schlagworte:
Transplantation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862276/
https://ncbi.nlm.nih.gov/pubmed/24055823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-519413
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