Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation

New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). We conducted a clinical trial of allogeneic T cells genetically modified to express a chimeric antigen receptor (CAR) targeting the B-cell antigen CD19. T cells for genet...

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Main Authors: Kochenderfer, James N., Dudley, Mark E., Carpenter, Robert O., Kassim, Sadik H., Rose, Jeremy J., Telford, William G., Hakim, Frances T., Halverson, David C., Fowler, Daniel H., Hardy, Nancy M., Mato, Anthony R., Hickstein, Dennis D., Gea-Banacloche, Juan C., Pavletic, Steven Z., Sportes, Claude, Maric, Irina, Feldman, Steven A., Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Jena, Bipulendu, Bishop, Michael R., Gress, Ronald E., Rosenberg, Steven A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society of Hematology 2013
Ábhair:
Transplantation
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3862276/
https://ncbi.nlm.nih.gov/pubmed/24055823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-519413
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