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Protein–Ligand Interactions: Thermodynamic Effects Associated with Increasing the Length of an Alkyl Chain
[Image: see text] Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and tripeptides of the general form Ac-pTyr-Xaa-Asn in which the Xaa residue bears a linear alkyl chain varying in length from 1–5 carbon atoms. Binding affinity increases upon adding a methy...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical
Society
2013
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3859442/ https://ncbi.nlm.nih.gov/pubmed/24349642 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml400211q |
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