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Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Nonpolar Surface Area
Thermodynamic parameters were determined for complex formation between the Grb2 SH2 domain and Ac–pTyr–Xaa–Asn derived tripeptides in which the Xaa residue is an α,α-cycloaliphatic amino acid that varies in ring size from 3- to 7-membered. Although the 6- and 7-membered ring analogs are approximatel...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3218293/ https://ncbi.nlm.nih.gov/pubmed/22007755 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2068752 |
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