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Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization

Structures of the Grb2 SH2 domain complexed with a series of pseudopeptides containing flexible (benzyl succinate) and constrained (aryl cyclopropanedicarboxylate) replacements of the phosphotyrosine (pY) residue in tripeptides derived from Ac-pYXN-NH(2) (where X = V, I, E and Q) were elucidated by...

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שמור ב:
מידע ביבליוגרפי
Main Authors: Clements, John H., DeLorbe, John E., Benfield, Aaron P., Martin, Stephen F.
פורמט: Artigo
שפה:Inglês
יצא לאור: International Union of Crystallography 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2954456/
https://ncbi.nlm.nih.gov/pubmed/20944243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910035584
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