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Binding of flexible and constrained ligands to the Grb2 SH2 domain: structural effects of ligand preorganization
Structures of the Grb2 SH2 domain complexed with a series of pseudopeptides containing flexible (benzyl succinate) and constrained (aryl cyclopropanedicarboxylate) replacements of the phosphotyrosine (pY) residue in tripeptides derived from Ac-pYXN-NH(2) (where X = V, I, E and Q) were elucidated by...
Gorde:
| Egile Nagusiak: | , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
International Union of Crystallography
2010
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2954456/ https://ncbi.nlm.nih.gov/pubmed/20944243 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444910035584 |
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