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Peptide Bicycles that Inhibit the Grb2 SH2 Domain

Developing short peptides into useful probes and therapeutic leads remains a difficult challenge. Structural rigidification is a proven method for improving the properties of short peptides. In this work, we report a strategy for stabilizing peptide macrocycles by introducing side-chain-to-side-chai...

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書誌詳細
主要な著者: Quartararo, Justin S., Wu, Pianpian, Kritzer, Joshua A.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3516885/
https://ncbi.nlm.nih.gov/pubmed/22689355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201200175
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