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Cytosolic delivery of peptidic STAT3 SH2 domain inhibitors
The signal transducer and activator of transcription 3 (STAT3) protein is constitutively activated in several cancers. STAT3 activity can be blocked by inhibiting its Src Homology 2 (SH2) domain, but phosphotyrosine and its isosteres have poor bioavailability. In this work, we develop peptide-based...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7294595/ https://ncbi.nlm.nih.gov/pubmed/32503696 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2020.115542 |
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