Preparation of crystals for characterizing the Grb7 SH2 domain before and after complex formation with a bicyclic peptide antagonist

Human growth factor receptor-bound protein 7 (Grb7) is an adapter protein involved in cell growth, migration and proliferation. It is now recognized that Grb7 is an emerging therapeutic target in specific cancer subtypes. Recently, the discovery of a bicyclic peptide inhibitor that targets the Grb7...

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Autores principales: Ambaye, Nigus D., Gunzburg, Menachem J., Traore, Daouda A. K., Del Borgo, Mark P., Perlmutter, Patrick, Wilce, Matthew C. J., Wilce, Jacqueline A.
Formato: Artigo
Lenguaje:Inglês
Publicado: International Union of Crystallography 2014
Materias:
Crystallization Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3936443/
https://ncbi.nlm.nih.gov/pubmed/24637751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S2053230X13033414
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