Insight into the Selectivity of the G7-18NATE Inhibitor Peptide for the Grb7-SH2 Domain Target

Growth factor receptor bound protein 7 (Grb7) is an adaptor protein with established roles in the progression of both breast and pancreatic cancers. Through its C-terminal SH2 domain, Grb7 binds to phosphorylated tyrosine kinases to promote proliferative and migratory signaling. Here, we investigate...

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Bibliografiska uppgifter
I publikationen:Front Mol Biosci
Huvudupphovsmän: Watson, Gabrielle M., Lucas, William A. H., Gunzburg, Menachem J., Wilce, Jacqueline A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2017
Ämnen:
Molecular Biosciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5623053/
https://ncbi.nlm.nih.gov/pubmed/29018805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2017.00064
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