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Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7
The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we...
Kaydedildi:
| Yayımlandı: | Sci Rep |
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| Asıl Yazarlar: | , , , , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Nature Publishing Group
2016
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4891710/ https://ncbi.nlm.nih.gov/pubmed/27257138 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27060 |
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