Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Gunzburg, Menachem J., Kulkarni, Ketav, Watson, Gabrielle M., Ambaye, Nigus D., Del Borgo, Mark P., Brandt, Rebecca, Pero, Stephanie C., Perlmutter, Patrick, Wilce, Matthew C. J., Wilce, Jacqueline A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891710/
https://ncbi.nlm.nih.gov/pubmed/27257138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27060
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