Unexpected involvement of staple leads to redesign of selective bicyclic peptide inhibitor of Grb7

The design of potent and specific peptide inhibitors to therapeutic targets is of enormous utility for both proof-of-concept studies and for the development of potential new therapeutics. Grb7 is a key signaling molecule in the progression of HER2 positive and triple negative breast cancers. Here we...

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Publicado no:Sci Rep
Main Authors: Gunzburg, Menachem J., Kulkarni, Ketav, Watson, Gabrielle M., Ambaye, Nigus D., Del Borgo, Mark P., Brandt, Rebecca, Pero, Stephanie C., Perlmutter, Patrick, Wilce, Matthew C. J., Wilce, Jacqueline A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4891710/
https://ncbi.nlm.nih.gov/pubmed/27257138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep27060
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