Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation

BACKGROUND: Human growth factor receptor bound protein 7 (Grb7) is an adapter protein that mediates the coupling of tyrosine kinases with their downstream signaling pathways. Grb7 is frequently overexpressed in invasive and metastatic human cancers and is implicated in cancer progression via its int...

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Autores principales: Porter, Corrine J, Matthews, Jacqueline M, Mackay, Joel P, Pursglove, Sharon E, Schmidberger, Jason W, Leedman, Peter J, Pero, Stephanie C, Krag, David N, Wilce, Matthew CJ, Wilce, Jacqueline A
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2007
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2131756/
https://ncbi.nlm.nih.gov/pubmed/17894853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1472-6807-7-58
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