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Thermodynamic and Structural Effects of Macrocyclic Constraints in Protein−Ligand Interactions
[Image: see text] The thermodynamic and structural effects of macrocyclization as a tactic for stabilizing the biologically active conformation of Grb2 SH2 binding peptides were investigated using isothermal titration calorimetry and X-ray crystallography. 23-Membered macrocycles containing the sequ...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Chemical Society
2010
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2992351/ https://ncbi.nlm.nih.gov/pubmed/21116482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml100142y |
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