Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

Brain aging is associated with diminished circadian clock output and decreased expression of the core clock proteins, which regulate many aspects of cellular biochemistry and metabolism. The genes encoding clock proteins are expressed throughout the brain, though it is unknown whether these proteins...

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Autores principales: Musiek, Erik S., Lim, Miranda M., Yang, Guangrui, Bauer, Adam Q., Qi, Laura, Lee, Yool, Roh, Jee Hoon, Ortiz-Gonzalez, Xilma, Dearborn, Joshua T., Culver, Joseph P., Herzog, Erik D., Hogenesch, John B., Wozniak, David F., Dikranian, Krikor, Giasson, Benoit I., Weaver, David R., Holtzman, David M., FitzGerald, Garret A.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2013
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3859381/
https://ncbi.nlm.nih.gov/pubmed/24270424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI70317
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